Have you ever plugged in a thumb drive or an external storage drive, and had that annoying Autoplay box come up? If you have a drive that you mount often and you know does not need to autoplay, you can disable it. You need to download Tweak UI (a Windows Powertoy).
In Tweak UI, go to My Computer > AutoPlay > Drives, then unselect the drives in which you want to turn AutoPlay off. In my example, this would be my E: and F: drives.